EN
cn 
100g/bag; 500g/bag; 1kg/bag; 25kg/drum
Address
No.567 Dengcai Street, Sandun, Westlake District, Hangzhou 310030, Zhejiang, China.
Vonoprazan Fumarate (TAK-438 CAS No.1260141-27-2), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+, K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease.
Synonym
Vonaprazan fumarate; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine2-butenedioate(Vonoprazan); 1-[5-(2-fluorophenyl)-1-pyridin-3-Chemicalbookylsulfonylpyrrol-3-yl]-N-methylmethanamine; AK-438; Vonaprazan(TAK-438); vonoprazan(tak-438); Vonoprazanfumarate(TAK-438); vonoprazan(tak-438)1260141-27-2
CAS No.: 1260141-27-2
EC No.: 250-635-4
MF: C21H20FN3O6S
MW: 461.46
Item | Specification | Results |
Appearance | Off-white To White Crystalline Powder | White Crystalline Powder |
Solubility | Soluble In Dmso, Slightly Soluble In Methanol, Water, Very Slightly Soluble In Alcohol. | Complies |
Identification | 1HNMR | Complies |
Melting Point | 196-201℃ | 198-199℃ |
Residue On Ignition | NMT0.2% | 0.03% |
Water | NMT0.5% | 0.12% |
Single Impurity | NMT0.1% | 0.034% |
Total Impurities | NMT0.5% | 0.121% |
Heavy Metals | NMT20PPM | Complies |
Assay | 99.0-101.0% | 99.69% |
100g/bag; 500g/bag; 1kg/bag; 25kg/drum
Store in a cool, dry and ventilated place.
2 - 8 °C
Antigastric drugs
