I.Introduction to 6-Paradol
Chemical name: 1-(4-hydroxy-3-methoxyphenyl)-decan-3-one, molecular formula C₁₇H₂₆O₃, is a hydrogenated derivative of gingerol, and exists in ginger and its processed products. Its lipid-soluble structure gives it good cell membrane penetration ability, and its bioavailability is better than that of gingerol precursors [1].
II.Mechanism of Action
1.Antioxidant Pathway
It activates the Nrf2/ARE signaling pathway, upregulates the expression of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and scavenges ROS (reactive oxygen species) [2].
2.Anti-inflammatory Regulation
Inhibits NF-κB and COX-2 pathways, reduces the release of pro-inflammatory factors such as TNF-α and IL-6, and experiments show that the inflammation inhibition rate of RAW 264.7 macrophages is as high as 62%[3].
3.Anti-tumor Effect
Induces apoptosis of tumor cells (such as colon cancer HT-29 cells) by activating Caspase-3 through the mitochondrial pathway and inhibits MMP-9-mediated metastasis[4].
III.Efficacy of 6-Paradol
1.Neuroprotection
In the Alzheimer's disease model, 6-Paradol (10 μM) can reduce β-amyloid protein deposition and improve cognitive function in mice (Morris water maze test shortened latency by 34% [5].
2.Metabolic Disease Intervention
By regulating PPARγ to enhance insulin sensitivity, animal experiments showed that 2 weeks of administration reduced fasting blood glucose in diabetic mice by 28% [6].
3.Skin Repair
Promote keratinocyte migration and accelerate wound healing (in vitro scratch test healing rate increased by 41%) [7].
IV.Conclusion
Scientific research has found that 6-Paradol, a natural active ingredient in ginger, may become a "multi-talent" for our health - from relieving inflammation to protecting cells, it has shown surprising potential. Although its best use still needs to be further verified, scientists are exploring more advanced technologies (such as nano-encapsulation) to enhance its effectiveness. In the future, this gift from nature may bring us safer and more effective health support solutions.
References
[1] ABMole. Paradol: Cyclooxygenase inhibitor and antitumor activity [EB/OL]. ABMole. 2025.
[2] PubMed. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) [J]. PMID:329900-75-6. 2025.
[3] Biopurify. 6-Paradol: Chemical properties and biological activities [EB/OL]. Biopurify. 2025.
[4] ChemicalBook. 27113-22-0: Physical and chemical properties of 6-Zingerol [EB/OL]. ChemicalBook. 2025.
[5] GBW. Technical parameters of 6-Paradol standard [EB/OL]. GBW. 2025.
[6] Selleck. 6-Paradol: Purity and NMR verification data [EB/OL]. Selleck. 2024.
[7] BioMart. Anti-inflammatory and hypoglycemic effects of 6-Paradol [EB/OL]. BioMart. 2024.
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