(-)-Quinine Hydrochloride 2-hydrat;CAS 6119-47-7

Item

Specification

Appearance

White to off-white powder

Identification

(A)-TLC：The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution.

(B)-Bromine and ammonia:A green colour develops when treated with bromine water and dilute ammonia.

(C)-IR Spectrum:When examined in ultraviolet light at 366 nm an intense blue fluorescence appears which disappears almost completely on the addition of 1ml of HCL.

(D)-Characteristic of chlorides:It gives the reactions of chlorides.

(E)Test for PH: Meets the standard.

Solubility

Soluble in water, freely soluble in ethanol(96%)

Appearance of Solution

Solution S is clear and not more intensely coloured than reference solution GY.

Specific Rotation

-240°~-226°

PH

6.0~6.8

Moisture(K.F)

6.0%-10.0%

Loss on Drying

6.0%~10.0%

Sulphated Ash

≤0.1%

Sulfate

≤500ppm

Titration With AgNO3

95.0% - 105.0%

Other Cinchona Alkaloids Impurity C

≤10.0%

Any Impurity Eluted Before Quinine

≤5.0%

Any Other Impurity

≤2.5%

Lead

≤ 10ppm

Arsenic

≤3ppm

Cadmium

≤1ppm

Mercury

≤1ppm

Barium

Meets the standard

Assay(HPLC)

99.0%-101.0% (On dried substance)