Tribenoside
Tribenoside (Tribenoside, TBS), namely ethyl-3,5,6-tribenzyloxy-D-glucopyranoside, is composed of two optical isomers (α-ethyl-3,5,6). -Tribenzyloxy-D-glucopyranoside) and β-body (β-ethyl-3,5,6-tribenzyloxy-ChemicalbookD-glucopyranoside). The drug was discovered and synthesized in the 1950s. It was first developed by Japan in 1999 as an oral drug for the treatment of hemorrhoids. Because of its strong fat-solubility, it is easily absorbed by the small intestine, and its drug utilization rate is high, so its clinical efficacy is relatively high. Other similar drugs have greatly improved.
Synonym
Glivenol; Glucofuranoside, ethyl 3,5,6-tri-O-benzyl- (7CI); Glucofuranoside, ethyl 3,5,6-tri-O-benzyl-, D- (8CI); Glyvenal; Glyvenol; Hemocuron; TBGF; Tribenzoside
● CAS No.: 10310-32-4
● EC No.: 233-687-2
● MF: C29H34O6
● MW: 478.58
Parameters of Tribenoside
|
Items Of Test |
Standard |
|
Appearance |
Yellowish To Pale Yellow, Viscous Liquid. |
|
Absorbency In Mentanol |
≤0.10 (420nm) |
|
Specific Optical Rotation |
-31.0 to -40.0° |
|
Identification |
IR Positive Reaction |
|
Solubility |
Practically Insoluble In Water, Soluble In Acetone, Methanol And Dichloromethane |
|
Related Substances HPLC |
Impurity A: ≤0.5% |
|
Impurity C: ≤ 0.5% |
|
|
Impurity D: ≤0.3% |
|
|
Other Single Impurity: ≤ 0.3% |
|
|
Total Other Impurity: ≤2% |
|
|
Heavy Metals [Pb] |
≤20ppm |
|
Content |
96.0-102.0% |
|
Residual Solvents |
Solvent A≤5000ppm |
|
Solvent B≤3000ppm |
|
|
Solvent C≤5000ppm |
● Packing: 100g/bag; 500g/bag; 1kg/bag; 25kg/drum
● Recommended storage method: Store in a cool, dry and ventilated place.
● Recommended storage temperature: 2-8°C
● Product usage: Oral medicine for hemorrhoids
