Sodium Colanate: Antioxidant, Water-retention Agent, Skin Protectant, And Humectan&moisturizer

Product name:  Sodium Colanate: Antioxidant, water-retention agent, skin protectant, and humectant/moisturizer
Chemical Structure:

Sodium Colanate is an extracellular anionic polysaccharide synthesized by gut probiotics, possessing exceptional immunomodulatory, anti-inflammatory, and moisturizing properties.

In 2017, scientists first revealed that Sodium Colanate can significantly extend the lifespan of living organisms.

Through years of research, our team has discovered that Sodium Colanate promotes the high expression of the NAMPT protein in human fibroblasts. This, in turn, regulates two key aging-related targets-NAD+ and Sirtuin 1-thereby significantly inhibiting cellular inflammation and apoptosis. Furthermore, it enhances cellular autophagy by suppressing the mTOR signaling pathway and maintains mitochondrial homeostasis by promoting the mitochondrial unfolded protein response, mitochondrial fission, and mitophagy. In addition, Sodium Colanate reduces the levels of reactive oxygen species (ROS) within cells and mitochondria, stimulates collagen expression, and strengthens intercellular communication.

Sodium Colanate: Antioxidant, water-retention agent, skin protectant, and humectant/moisturizer.

Sodium Colanate is a "mitochondria-targeting anti-aging polysaccharide" that offers the following specific skincare benefits:

1. Anti-aging and Collagen Regeneration

Clinical test data show that after 28 days of using products containing Sodium Colanate, skin collagen content increased by 22%, and wrinkles were reduced by 36%. It addresses key markers of aging, such as "mitochondrial dysfunction," and promotes the "regeneration of the extracellular matrix (ECM)." In vitro cellular studies demonstrate that, at equivalent concentrations, it exhibits stronger anti-aging efficacy than Pro-Xylane (Hydroxypropyl Tetrahydropyrantriol) or Retinyl Propionate, while potently stimulating the regeneration of Type I and Type III collagen.

2. Hydration and Barrier Repair

Sodium Colanate improves overall skin condition by supporting the stability of the extracellular matrix (ECM) microenvironment and maintaining skin hydration.

It is recommended for use in skincare for mature skin, eye-area care, post-sun exposure recovery, and post-procedural skin repair.

3. Anti-inflammatory and Antioxidant Properties

Sodium Colanate possesses "excellent anti-inflammatory and antioxidant capabilities," effectively scavenging free radicals and mitigating oxidative stress. Consequently, it is well-suited for products designed for sensitive skin and cellular repair.

4. Cellular Energy and Mitochondrial Repair

Sodium Colanate aids in "repairing damaged mitochondria and enhancing the efficiency of cellular energy metabolism," while regulating processes such as cellular inflammation, apoptosis, autophagy, and mitochondrial homeostasis.

Years of research have shown that Sodium Colanate can promote the high expression of NAMPT protein in human fibroblasts, thereby regulating two intracellular aging targets, NAD+ and sirtuin 1, significantly inhibiting cellular inflammation and apoptosis; it enhances autophagy activity by inhibiting the mTOR signaling pathway; and it maintains mitochondrial homeostasis by promoting the unfolded mitochondrial protein response, mitochondrial division, and mitophagy. Furthermore, Sodium Colanate can reduce reactive oxygen species levels in cells and mitochondria, promote collagen expression, and enhance intercellular communication.

Ghichem's Sodium Colanate production and synthesis process involves microbial fermentation, with both carbon and nitrogen sources derived from plants, making the entire production process green and sustainable.

Gihichem has achieved the world's first industrial-scale production of Sodium Colanate across its entire molecular weight spectrum by constructing highly stable, high-yield, and low-endotoxin cell factories, combined with optimized enzymatic hydrolysis technology. This makes Gihichem one of the world's first companies to commercialize Sodium Colanate.

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