Mussel Adhesive Protein; Recombinant Mussel Adhesive Protein; MAPs; Marine Mussel Adhesion; Lyophilized Powder; Solution

Product name: Mussel Adhesive Protein; Recombinant mussel adhesive protein; MAPs; Marine Mussel Adhesion; Lyophilized powder; Solution

Product Information:

Mussel adhesive proteins (MAPs) are natural proteins derived from Mytilus edulis, renowned for their exceptional adhesive properties. These proteins, rich in 3,4-dihydroxyphenylalanine (DOPA) residues, enable mussels to adhere firmly to surfaces in challenging environments. Due to these unique biochemical and mechanical characteristics, MAPs have attracted significant attention in the biomedical field, offering promising applications in wound healing, drug delivery, tissue engineering, and cosmetics. Recombinant MAPs (rMAPs), in particular, hold great potential due to their enhanced properties, including antioxidant, anti-inflammatory, antibacterial, and cell-protective effects. They are increasingly being explored for their role in tissue repair, skin regeneration, and targeted drug delivery systems.

Mussels, with their tough byssal threads, withstand the impacts of strong winds and waves. This admirable biological force originates from a special substance secreted by the mussel's byssal gland called mussel adhesive protein.

This protein exhibits remarkable adhesive properties underwater, granting it powerful potential for biological repair.

Researches have found that mussel adhesive protein is rich in positively charged amino acids and dopa groups; the positively charged groups can attract negatively charged cells, effectively aiding cell migration and wound healing; the dopa groups not only have strong anti-inflammatory and antioxidant functions, but also can form microscopic network structures through self-crosslinking to quickly form a film, maintaining the health of the skin barrier. The mussel adhesive protein, with its outstanding performance and rarity, is known as "ocean soft gold". However, traditional animal-derived methods have low yields and produce complex and variable components, with risks of virus transmission and immunogenicity. Now, gihichem has developed a dual-core platform combining synthetic biology and artificial intelligence to express the mussel adhesion protein gene sequence in microbial chassis. Recombinant proteins are highly stable and productive , with each cubic fermentation tank potentially replacing the extraction from hundreds of millions of cultured mussels, breaking through the bottlenecks of large-scale industrialization.

Our Advantages:

1. World's Highest Production Volume Recombinant Mussel Adhesive Protein Strains

• Mussel protein boasts the highest theoretical dopa content (44% by mass, 28% by molar).
• The world's highest expression level gene sequence for mussel protein.
• Independent black-box sequence optimization strategy.
•  Unique high-copy assembly technology.

2. Unique Tyrosinase Modification Technology

• Unique tyrosinase modification technology precisely controls the oxidation of tyrosine groups to DOPA, avoiding excessive oxidation to quinone.
• Precise control of dopa content through enzyme kinetics.

3. Long-Term Stability Technology and Process

• Long-term product stability: No significant discoloration during shelf life (yellowing occurs after oxidation to quinone).
• Molecularly rational design and optimized formulation process achieve long-term stable storage in both solid and liquid phases.