Colistimethate Sodium; Sodium Colanate; Sodium Colamin; Colominic Acid Sodium Salt; Polysialic Acid Sodium Salt; CAS 70431-34-4

Product name:  Colistimethate Sodium; Sodium Colanate; Sodium Colamin; Colominic Acid Sodium Salt; Polysialic Acid Sodium Salt

CAS: 70431-34-4
Chemical Structure:

Colistimethate Sodium, also called Colominic acid sodium salt (Polysialic acid sodium salt) could be naturally isolated from the cell wall of Escherichia coli and animals, gives a red color which has an absorption maximum at 530 nm. Colominic acid sodium salt (Polysialic acid sodium salt) possesses anti-bacterial activity.

Colistimethate Sodium is an extracellular anionic polysaccharide synthesized by probiotics in the gut, possessing remarkable immunomodulatory, anti-inflammatory, and moisturizing effects.

In 2017, scientists first revealed that Colistimethate Sodium can significantly extend the lifespan of living organisms.

Years of research have shown that Colistimethate Sodium can promote the high expression of NAMPT protein in human fibroblasts, thereby regulating two intracellular aging targets, NAD+ and sirtuin 1, significantly inhibiting cellular inflammation and apoptosis; it enhances autophagy activity by inhibiting the mTOR signaling pathway; and it maintains mitochondrial homeostasis by promoting the unfolded mitochondrial protein response, mitochondrial division, and mitophagy. Furthermore, Colistimethate Sodium can reduce reactive oxygen species levels in cells and mitochondria, promote collagen expression, and enhance intercellular communication.

Ghichem's Colistimethate Sodium production and synthesis process involves microbial fermentation, with both carbon and nitrogen sources derived from plants, making the entire production process green and sustainable.

Gihichem has achieved the world's first industrial-scale production of Colistimethate Sodium across its entire molecular weight spectrum by constructing highly stable, high-yield, and low-endotoxin cell factories, combined with optimized enzymatic hydrolysis technology. This makes Gihichem one of the world's first companies to commercialize Colistimethate Sodium.

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