Palmitoylethanolamide (PEA) is a naturally occurring compound in the body that helps to fight pain and inflammation. It is also produced by many animals and plants, with the highest concentrations found in soy lecithin, soy, egg yolk, peanuts, and alfalfa. PEA is technically known as a "pro-resolving lipid mediator." This means that PEA affects central control mechanisms inside cells, resolving inflammation and cellular stress. Over 600 scientific studies have demonstrated its highly beneficial effects.
PEA has a wide range of potential clinical applications, but its research and popular use is mainly focused on its anti-inflammatory and analgesic effects in diseases such as low back pain, sciatica, and osteoarthritis. Preclinical and human studies have also investigated its effects on depression, enhanced cognitive function and memory, autism spectrum disorders, multiple sclerosis, obesity, and metabolic syndrome. PEA has many characteristics similar to cannabidiol (CBD), but its use is better supported by science, which is its advantage.
The health benefits of palmitoylethanolamide bulk powder include influencing immune cells that control inflammation (especially in the brain). PEA may help reduce the production of inflammatory substances. However, PEA primarily acts on cellular receptors that control various aspects of cellular function. These receptors are called PPAR. PEA and other compounds that help activate PPAR can relieve pain and promote metabolism by consuming fat, reducing serum triglycerides, increasing serum high-density lipoprotein cholesterol, improving blood sugar control, and helping to lose weight.
If Palmitoylethanolamide can help alleviate brain inflammation, can it also work on other brain-related problems?
Yes, PEA has a comprehensive mechanism that plays a critical role in chronic pain, cognitive function, and depression. There is considerable evidence that PEA plays a significant role in alleviating depression-induced by cognitive impairment and chronic pain. Animal models of depression and human double-blind placebo-controlled trials have all shown antidepressant effects. Studies have also shown that PEA can help alleviate stress responses, thus providing an essential protective effect against stress and anxiety.
Low back pain
Carpal tunnel syndrome
Peripheral neuropathy -diabetic neuropathy & chemotherapy-induced peripheral neuropathy
Neuropathic pain -stroke-related & multiple sclerosis
Chronic pelvic and vaginal pain
Postherpetic neuralgia from viral skin problems
Palmitoylethanolamide (PEA) is completely safe and non-toxic, and in human clinical trials, PEA has no significant treatment-related side effects. No known drug interactions exist with PEA.